Breast Conservation Therapy for Invasive Breast Cancer in Ashkenazi Women With BRCA Gene Founder Mutations
نویسندگان
چکیده
منابع مشابه
Breast conservation therapy for invasive breast cancer in Ashkenazi women with BRCA gene founder mutations.
BACKGROUND Germline mutations in the BRCA1 and BRCA2 genes are associated with an increased risk of breast cancer. Whether women with breast cancer who have inherited mutations in these genes have a different outcome after breast conservation therapy than women with "sporadic" cancer is unresolved. Consequently, we compared the outcomes after breast conservation therapy in Ashkenazi women with ...
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We ascertained 184 Ashkenazi Jewish women with breast/ovarian cancer (171 breast and 13 ovarian cancers, two of the former also had ovarian cancer) in a self-referral study. They were tested for germline founder mutations in BRCA1 (185delAG, 5382insC, 188del11) and BRCA2 (6174delT). Personal/family histories were correlated with mutation status. Logistic regression was used to develop a model t...
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متن کاملTITLE: Influence of Radiotherapy and Tamoxifen on Contralateral Cancer Risk in Women with Hereditary Breast Cancer PRINCIPAL INVESTIGATOR:
Background: The prognostic significance of germiine mutations in BRCA1 and BRCA2 In women with breast cancer remains unclear. A combined analysis was performed to address this uncertainty. Methods: Two retrospective cohorts of Ashkenazi Jewish women undergoing breast-conserving treatment for invasive cancer between 1980 and 1995 (n=584) were established. Archived tissue blocks were used as the ...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 1999
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/91.24.2112